The Science Behind Reverse Aging

This is the third in a series of articles on reversing aging or how to reclaim your youth and vitality! You can read the second article here: Biological vs Chronological Age. While a lot of research has been done on the subject, a recent one was actually successful in reversing the process of aging in mice.

The study indicated that not only did the mice appear younger but that their lifespan was extended by approximately 30 percent. And while the study has only been done on mice, the researchers are hopeful that the same would be ready for human trials within ten years.

Epigenetics

The basis of this research was something called epigenetics. By definition, this means the study of inherent changes in gene function. As we move through life, our genetic makeup changes in many different ways.

For instance, outside factors such as environmental pollutants like smoking or lifestyle habits like alcohol and drug dependency can bring about changes. And with a change in our genes, our bodies change as well. When the body changes, it starts to age.

Whether these changes promote a predisposition to an inherited condition such as heart disease, diabetes or arthritis or create a new condition that the body remains unable to recover from.

Such epigenetic changes supply a lot of information for why these things happen. And when scientists find out why these changes happen they can work on a way of stopping them from happening or even reversing them such as in aging.

Scientists have also determined an age reversing agent known as nicotinamide adenine dinucleotide or NAD+. This compound was present more in younger mice than older ones and is very important in repairing DNA damage.

There is also another DNA repair agent called PARP1 which does respond well to NAD+ levels in the human body. So the higher the NAD+, the more PARP1.

Younger individuals, much like younger mice, have higher levels and these levels start to fall as people age. This, in turn, makes it harder for DNA to restore itself. So with this in mind, scientists gave more NAD+ to older mice and sure enough, they started to appear younger, biologically.

As a takeaway, research findings concluded that by changing adult cells into their earlier stage, reverse aging may be set in motion.

But that is for the scientists to do. As for your part, what you can do to reverse aging is to take better care of yourself to stop cellular damage at different levels. Once your cells are working well, they are in a stronger position to repair DNA themselves and stop aging prematurely.

What Else Does Science Say?

Science has a whole lot more to say about reverse aging, but we will only look at some basics here. Just enough to get an idea about established research into the topic.

Genetic Component

Looking for a way to halt aging has undoubtedly stepped into science labs to unlock the mysteries of aging. In fact, research believes that not only may we be close to stopping aging but actually reversing it as well.

For starters, as mentioned earlier, your genes have a big role in how fast or slow you age. But because genes are something beyond your control, here is what you need to know about genes affecting the aging process.

DNA research has shown that specific genes are responsible for aging. Collectively dubbed as ‘late life cyclers’, this set of genes activate only in later life or during bouts of intense stress.

Stressors relators to aging such as molecular and cellular damage, oxidative stress and even some disease states cause these genes to respond. Plus some of these genes have been studied to be more active in individuals with cancer, creating more responses in such people and signaling a higher level of distress. All of this activity will quickly age you taxing not only your looks but also your health.

The same set of genes are also activated if something called the circadian rhythm is out of sync.

Circadian Rhythm

One element that needs to be maintained well is a person’s circadian rhythm. This is roughly your 24-hour cycle, or body clock which determines your physical, mental and behavioral patterns. In other words, daily routines from waking up to going back to sleep all fall within your circadian rhythm. It is also known as your sleep/wake cycle.

So what you do during this sleep/wake cycle can actually determine the state of your overall health. Your circadian rhythm works best when you have regular sleep habits such as going to bed at a good hour and waking up early in the morning (incidentally, the circadian rhythm also coincides with sunrise and sundown).

With your circadian rhythm disrupted, eating and sleeping patterns can run amok which will naturally have a say in how you age. So as a heads up for what’s coming on later articles, it is important to eat and sleep well to reverse the effects of aging.

Hormonal Decline

Hormones are natural chemicals produced in one part of the body, released into the bloodstream and then used by other organs and systems.

These hormones also start to get out of whack as we age. Typically, the levels of hormone production in the body start to slow down as you near 30. In particular, regulatory hormone production like estrogen and testosterone declines and many bodily function/ features start to get affected.

There are different hormones involved in the aging process like adrenal, thyroid, sex and metabolic hormones. Together, they are responsible for a wide variety of health concerns like body composition, bone health, energy levels, and brain function among many others.

These declining hormone levels make the body less capable of regulating these functions as we start to experience age-related symptoms like cognitive decline, weight gain, lower muscle strength and endurance as well as dry skin and hair loss.

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